Aspirin because I used to run ultras where they sometimes ban NSAIDs because it can cause acute kidney injury in those kinds of scenarios (rhabdomyolysis) but ibuprofin is the worst of the two.

And I don’t fuck around with tylenol ever because the effective dose is pretty damn close to a toxic dose and if you drink alcohol forget about it altogether.

But NSAIDs also inhibit bone remodeling so I tend to just avoid them altogether, running and all. Some cells in/on your bones (osteoblasts) rely on inflammation as a cue to shit out new bone, so reducing inflammation kinda messes with that