On Earth, the cardinal directions are straightforward. The arrow on a compass points to the nearest magnetic pole. You can then use it to travel anywhere on Earth.
In space, the idea of anything being “central” enough to be used as a “North” (since the universe has no center) or being fixated enough to not somehow pose issues is more convoluted.
If you were a pioneer of space exploration, what would your “North” be?
Cosmic background radiation provides a stable frame of reference for setting up a coordinate system. If the explorers have a main HQ base, it can be set as the origin (0,0,0). The location of an object in space can be communicated using a tuple like (10km, 30°, 30°), representing the radius (distance to the object), polar angle (angle between the positive z-axis and the line connecting the origin to the point), and azimuthal angle (angle between the positive x-axis and the line connecting the origin to the point on the xy-plane).
Alternatively, if only a general region is needed, grid coordinates can be used with any useful unit of measurement for the distance between grid lines.