Yes, entirely possible. I’ve been using Linux off and on since 2006 and full time as my daily driver since 2018ish. I’ve used Ubuntu, Fedora, Open Suse, Endevour OS, Manjaro and various combos of those in that time. I barely use CLI, bar distro updates and a few basics. The fact that you need to use the CLI is a complete myth. I see a lot of responses stating “yeah, but why would you want to?” . That, frankly, is gatekeeping. I fully respect those who choose to use the CLI as a powerful too, I fully understand their position. But if someone chooses not to, because they aren’t as used to it or just prefer to us a mouse to click around then yes it is possible, and they should be encouraged to run a Linux distro if they want to.
If I had read many of the responses below, back in 2006, I may not have tried Ubuntu when I did and may not be still using Linux to this day.
Windows 3.11 and Kubuntu 6.06LTS (still have the CD!)