Piggyback on to this excellent comment to elaborate on modding New Vegas. Everything except NVR works great! I’d recommend using this to install MO2
4GB patcher has a Linux specific version on the Nexus Mods page.
You can run most tools like the BSA decompressor or the TTW installer using Protontricks.
xLODGen can be added as a tool to MO2 and just works.
Their not worried about it