• marcos@lemmy.world
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      25 days ago

      Also, it’s bothering me that it’s not immediate.

      If he was going to be wooshed, he could at least get the details right…

  • Geodad@lemmy.world
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    25 days ago

    This is how amatoxins from mushrooms kills you. They shut down mRNA synthesis in the liver.

    • Otter@lemmy.ca
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      25 days ago

      The amanitin toxin is heat stable, remaining toxic whether eaten raw or cooked. The mechanism of action of amatoxin is by inhibiting RNA polymerase, causing disruption of transcription of mRNA. As a result, hepatocytes cannot synthesize key protein coding genes, leading to the disintegration of nucleoli and pathologically centrilobular hepatic necrosis. This leads to the insidious onset of liver failure over 48 hours. Late onset (more than six hours after ingestion) of vomiting and watery diarrhea occur due to the second component in some of these mushrooms which are phallotoxin. Lepiota species lack phallotoxins so may not have the onset of vomiting and diarrhea until after 12 hours post-ingestion, or may just present with symptoms of liver failure at 24 hours post ingestion.

      https://www.ncbi.nlm.nih.gov/books/NBK431052/

      Wow ok 😬

      • TexasDrunk@lemmy.world
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        25 days ago

        I love reading about Death Cap mushrooms and their cousin, Destroying Angel. By the time symptoms appear, you’ve already got irreversible damage. Specifically for Destroying Angel, as of 2016 there was about a 50 percent survival rate, but by 2023 that number had jumped to 85-90%. There’s no antidote. Mostly treatment is to hydrate the absolute fuck out of you so that you’re peeing out the toxin and pumping you full of electrolytes. The key to survival is detecting it as soon as possible.

        • Geodad@lemmy.world
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          24 days ago

          Also denying food and drink. The toxin mixes with bile salts and is put back into the stomach by the gallbladder.

          Secondary poisoning.

  • Agent641@lemmy.world
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    24 days ago

    Certain temperatures can completely denature viruses like HIV and covid. Anything above 600 degrees should do the trick.

  • usernamesAreTricky@lemmy.ml
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    25 days ago

    First they fixate over protein metrics, and now they don’t want the actual protein synthesis? Having high intake of amino acids was already not doing most of what they claimed, but now we’re just gonna have our body not even use them? What a waste of resources. 0/10 (/s)

  • hperrin@lemmy.ca
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    24 days ago

    While you’re at it, can you take out all the acid and all the chemicals?