Personally, it’s Faith from Farcry 5 for me. Uninteresting dialog that can be summed up to “I was bullied once” and that’s it. Literally every other character is so much more interesting. Jacob gives you a sequence where you run through a gulag which he then uses against you, John tries to kill you and is openly hateful towards you plus is a character you get to interact with, and Joseph is a lunatic who was right.
Yeah, I was puzzled when OP listed Faith as most annoying; I don’t think they paid attention to the story.
I found her more interesting than many other Far Cry antagonists, let alone other video games characters.