Human glia derived myelin sheaths are better, faster, and, in some mutants, can repair damaged sheaths better than rodent ones. Since myelin is what makes the action potential travel fast and efficiently along a neuron, this means smarter mice. Since there’s generally very little immune activity in the CNS, you have a much lower chance of rejection.
Glial cells, not neurons.
https://www.scientificamerican.com/blog/guest-blog/human-brain-cells-make-mice-smart/
Human glia derived myelin sheaths are better, faster, and, in some mutants, can repair damaged sheaths better than rodent ones. Since myelin is what makes the action potential travel fast and efficiently along a neuron, this means smarter mice. Since there’s generally very little immune activity in the CNS, you have a much lower chance of rejection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700730/#ABS1title