One can build up a tolerance to iocaine by gradually ingesting trace doses over time.
It comes from Australia.
Ok so i am new to this https://www.yahoo.com/entertainment/really-build-immunity-iocane-powder-162927341.html?guccounter=1
DOES SOMETHING LIKE IOCANE EXIST? As previously noted, iocane is a made-up poison, invented for the story.
Like iocane, arsenic doesn’t have a taste or an odor, and it can be dissolved in liquid.
The major difference between arsenic and iocane powder — and it is admittedly a big difference — is that arsenic doesn’t kill immediately.
When it comes to arsenic, our real-world allegory of iocane powder, it doesn’t appear as though you can build up a tolerance through increasing low-level exposure.
A community located in a village in the Andes appears to have adapted a genetic tolerance to arsenic over the course of thousands of years